Nurofen Plus provides powerful pain relief. Particularly effective for back pain, neuralgia, dental pain and period pain and migraine headache, for those times when powerful pain relief is essential. Dosage: Adults (all indications except migraine: Initial dose of 2 tablets and then, if necessary, 1 or 2 tablets every 4-6 hours. Do not exceed 6 tablets daily. Children over 12 years of age: Initial dose of 2 tablets and then, if necessary, 1 or 2 tablets every 4-6 hours. Do not exceed 6 tablets daily. Children 7 to 12 years of age: Nurofen Plus is not suitable for children 12 years and under

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. Headache Abdominal pain Constipation Drowsiness Nausea Indigestion (dyspepsia) Ulceration of the stomach or intestine Dizziness Bleeding from the stomach or intestine Hypersensitivity reactions such as narrowing of the airways (bronchospasm), swelling of the lips, throat and tongue (angioedema), itchy blistering rash or anaphylactic shock Kidney disorders The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

How does it work? This medicine contains two active ingredients, ibuprofen and codeine phosphate. Both are pain-relieving medicines. Ibuprofen is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). It relieves pain and inflammation. Ibuprofen works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is an enzyme involved in the production of various chemicals in the body. Some of these natural chemicals are known as prostaglandins, and are produced by cyclo-oxygenase in response to injury or certain diseases and conditions. Prostaglandins cause pain, swelling and inflammation. By blocking the action of cyclo-oxygenase, ibuprofen stops the production of these inflammatory prostaglandins, and therefore reduces inflammation and pain. Codeine phosphate is a type of painkiller called an opioid. It is related to morphine but is not as strong. Opioid painkillers work by mimicking the action of naturally occurring pain-reducing chemicals called endorphins. Endorphins are found in the brain and spinal cord and reduce pain by combining with opioid receptors. Codeine phosphate mimicks the action of natural endorphins by combining with the opioid receptors in the brain and spinal cord. This blocks the transmission of pain signals sent by the nerves to the brain. Therefore, even though the cause of the pain may remain, less pain is actually felt. This combination of painkillers can be used to relieve pain and inflammation associated with various conditions. These include rheumatic, arthritic and muscular aches and pains, sprains and strains, period pains, headache and migraine, backache, dental pain and neuralgia. Migraine Headache There is often confusion between a bad headache and a migraine. However, migraines tend to be more painful, and sufferers may experience distinct symptoms (such as an aura), which can be distressing. Powerful pain relief is available in the form of Nurofen Plus, which can be effective in relieving the pain associated with migraine. The combination of ibuprofen plus codeine provides powerful dual action relief, both at the site of pain and in the central nervous system to reduce the perception of pain.