FemHRT warning: Combination hormone replacement therapy (estrogen and progestin HRT) should not be used to treat heart disease. Two-drug combination hormone replacement therapy can infrequently cause cancer of the breast, heart disease (e.g., heart attack), stroke, dementia, or blood clots in the lung (pulmonary embolism) or leg. Estrogens may also increase the risk of cancer of the ovary. These risks appear to depend on the length of time this combination is used and the amount of estrogen per dose. Therefore, two-drug HRT should be used for the shortest possible length of time at the lowest effective dose, so you obtain the benefits and minimize the chance of serious side effects from long-term treatment. Discuss the risks and benefits with your doctor. If you use this medicine for an extended period, you should be evaluated at least once a year. See Cautions section. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are also taking corticosteroids (e.g., prednisone), hydantoins (e.g., phenytoin), warfarin, drugs which affect certain liver enzymes (CYP450-3A4 enzymes) such as azole antifungals (e.g., ketoconazole, itraconazole), carbamazepine, macrolide antibiotics (e.g., clarithromycin, erythromycin), phenobarbital, rifamycins, (e.g., rifampin), ritonavir, cimetidine, or St. John's wort. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including a family medical history (especially for breast lumps or cancer), asthma, diabetes, seizures, migraine headaches, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), kidney disease, low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy (toxemia), yellowing of the eyes and skin (cholestatic jaundice) during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids, endometriosis), cholesterol or lipid problems, gallbladder disease, excessive weight gain, certain blood disorders (porphyria), allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have undiagnosed abnormal vaginal bleeding, cancer (e.g., of the breast or ovary), blood clots, liver disease, or active/recent stroke or heart attack. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.