Zyloprim (Allopurinol) is an anti-hyperuricemic/anti-gout medication used to lower blood uric acid and to prevent gouty arthritic attack. It is also used for the treatment of secondary hyperuricemia (elevated blood uric acid) which may occur during treatment of tumors or leukemia and to prevent recurrent calcium oxalate stones.
Possible adverse reactions with Zyloprim (Allopurinol) are: skin rash (in rare cases severe reaction); nausea, vomiting, abdominal pain; drowsiness, numbness and tingling of fingers and/or toes; muscle weakness; kidney and liver disorder.
What other drugs will affect allopurinol?
• Taking ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox, others) may increase the risk that a rash will develop during allopurinol therapy. Tell your doctor that you are taking allopurinol if you need to take ampicillin or amoxicillin.
• Thiazide diuretics (water pills) may increase the amount of allopurinol in your blood. Tell your doctor if you are taking a diuretic such as
· hydrochlorothiazide (Hydrodiuril, Hygroton, HCTZ, others),
· chlorothiazide (Diuril, others),
· chlorthalidone (Thalitone, others), or
· indapamide (Lozol).
• Allopurinol may also increase the effects of the certain other drugs. Before taking allopurinol, tell your doctor if you are taking any of the following medicines:
· azathioprine (Imuran),
· mercaptopurine (Purinethol),
· drugs used to treat cancer,
· cyclosporine (Sandimmune, Neoral),
· chlorpropamide (Diabinese),
· warfarin (Coumadin), or
· theophylline (Theochron, Theolair, Theo-Dur, others).
• You may require a dosage adjustment or special monitoring if you are taking any of the drugs listed above.
• Drugs other than those listed here may also interact with allopurinol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.