ESTRACE side effects, that may go away during treatment, include dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, or breast tenderness. If ESTRACE side effects continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience ESTRACE side effects like mental/mood changes (e.g., severe depression, memory loss), calf pain/swelling, sudden severe headache, chest pain, trouble breathing, one-sided weakness, slurred speech, vision changes (e.g., change in contact lens fit, loss of vision) breast lumps, swelling of hands or feet, changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, or prolonged bleeding), unusual vaginal discharge/itching/odor, or yellowing of eyes or skin. ESTRACE side effects are unlikely but seek immediate medical attention if i ESTRACE side effects occur. ESTRACE side effects include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other ESTRACE side effects not listed above, contact your doctor, nurse, or pharmacist.