Order ZYRTEC D (Cetirizine/Pseudoephedrine). ZYRTEC D (Cetirizine/Pseudoephedrine) is suited to treat allergy symptoms such as runny or watery nose, itchy or watery eye(s), and sneezing. ZYRTEC D (Cetirizine/Pseudoephedrine) can be taken once or twice daily as required to resolve allergy symptoms. You should not take ZYRTEC D (Cetirizine/Pseudoephedrine) if it is too close to bedtime because the pseudoephedrine component of ZYRTEC D (Cetirizine/Pseudoephedrine) may disrupt your sleep.