Chemical Name : Bumetanide/Potassium Chloride
Bumex K Information : Burinex K (Bumetanide/Potassium Chloride) the treatment of oedema where potassium supplementation is necessary.
Indications: Adults: The recommended initial dose is 2 tablets to be taken once daily (morning or evening). This may be increased up to 4 tablets daily (given as a single dose or in divided doses if preferred), or reduced to 1 tablet daily according to clinical response. If more than 4 tablets are to be taken daily, it is preferred to administer the diuretic and potassium supplement as 2 separate preparations. Elderly: Adjust dosage according to response. A dose of 1 tablet per day may be sufficient in some elderly patients.
Burinex K tablets must be swallowed whole and never chewed. The tablets should be swallowed with at least 100ml of water. Children: Not recommended in children under 12 years.
Bumex K Side Effects : As with other diuretics, fluid and electrolyte balance may be disturbed as a result of diuresis after prolonged therapy. This may cause symptoms such as headache, hypotension and myalgia. Electrolyte disturbances which may occur include hyponatraemia, hypomagnesaemia and hypokalaemia. The hypokalaemic effect of bumetanide is counteracted by the potassium content but hypokalaemia may not be totally prevented.
Other reactions to bumetanide include gastrointestinal disorders (e.g. nausea, vomiting, diarrhoea or constipation, abdominal pain/cramps, dyspepsia), muscle cramps, dehydration, hypotension, dizziness or vertigo, fatigue, headache, encephalopathy (in patients with pre-existing hepatic disease), hyperuricaemia, raised blood urea and serum creatinine, hyperglycaemia, alkalosis, skin rashes, gynaecomastia or painful breasts, arthralgia, allergic reactions, vasculitis, thrombocytopenia, leucopenia.
Bone marrow depression associated with the use of Burinex has been reported rarely but it has not been proven definitely to be attributed to the drug. Hearing disturbance after administration of Burinex is rare and reversible.
Burinex K should not be used with potassium sparing diuretics, (e.g. spironolactone, triamterene or amiloride) or in patients with renal insufficiency.
As with other diuretics, Burinex K should not be administered concurrently with lithium salts. Diuretics can reduce lithium clearance resulting in high serum levels of lithium.
All solid forms of potassium medication are contra-indicated in the presence of obstruction in the digestive tract (e.g. resulting from compression of the oesophagus due to dilation of the left atrium or from stenosis of the gut).
Anuria, Crohn's Disease, hyperkalaemia, precomatose states associated with liver cirrhosis, Addison's Disease, known hypersensitivity to bumetanide or Burinex.
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