ESTRADERM (ESTRADIOL) is a female hormone and is usually given to women who no longer produce the proper amount. ESTRADERM (ESTRADIOL) is used to reduce menopause symptoms (e.g., hot flashes, vaginal dryness), to prevent bone loss (osteoporosis) in people at high risk, and to treat other conditions as determined by your doctor. ESTRADERM (ESTRADIOL) is available as a patch in 3 doses (50mcg, 75mcg and 100mcg). ESTRADERM (ESTRADIOL) is now available as a generic.If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. There are several medicines (e.g., raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen therapy.

ESTRADERM side effects, that may go away during treatment, include dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, breast tenderness, or skin redness/irritation at the application site. If ESTRADERM side effects continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience ESTRADERM side effects like mental/mood changes (e.g., severe depression, memory loss), calf/pain swelling, sudden severe headache, chest pain, trouble breathing, one-sided weakness, slurred speech, vision changes (e.g., change in contact lens fit, loss of vision), breast lumps, swelling of hands/feet, changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, or prolonged bleeding), unusual vaginal discharge/itching/odor, or yellowing of the eyes/skin. ANESTRADERM side effects are unlikely, but seek immediate medical attention if ESTRADERM side effects occurs. Symptoms of ESTRADERM side effects include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other ESTRADERM side effects not listed above, contact your doctor, nurse, or pharmacist. WARNING: Estrogens have been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause, especially in women with a uterus who receive estrogen-only hormone therapy. Estrogens may also increase the risk of cancer of the ovary/breast. Estrogen-containing medicines should not be used to prevent heart disease. Estrogen given in combination with another hormone (progestin) for replacement therapy can infrequently cause heart disease (e.g., heart attacks), stroke, serious blood clots, dementia, and cancer of the breast. These risks appear to depend on the length of time this medicine is used and the amount of estrogen per dose. Therefore, ESTRADERM (ESTRADIOL) should be used for the shortest possible length of time at the lowest effective dose, so you obtain the benefits and minimize the chance of serious ESTRADERM side effects from long-term treatment. Consult your doctor or pharmacist for details. If you use this medicine for an extended period, you should be evaluated at least once yearly (see CAUTIONS section). ESTRADERM (ESTRADIOL) is not effective in preventing/treating a tendency toward miscarriages nor the threat of miscarriage. ESTRADERM (ESTRADIOL) must not be used during pregnancy because its use may result in ESTRADERM side effects like birth defects or cancer later in the child's life (see CAUTIONS section). INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking corticosteroids (e.g., prednisone), hydantoins (e.g., phenytoin), or warfarin. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking any medicines which may lead to ESTRADERM side effects like liver enyzymes (CYP450-3A4 enzymes) including azole antifungals (e.g., ketoconazole, itraconazole), carbamazepine, cimetidine, macrolide antibiotics (e.g., clarithromycin, erythromycin), phenobarbital, rifamycins (e.g., rifampin), ritonavir, or St. John's wort. DO NOT START OR STOP ANY MEDICINE without doctor or pharmacist approval. Inform your doctor of any other ESTRADERM side effects including a family medical history (e.g., especially breast lumps/cancer), asthma, diabetes, seizures, migraine headaches, kidney disease, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy, yellowing of eyes/skin during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids/endometriosis), cholesterol/lipid problems, gallbladder disease, excessive weight gain, certain blood disorder (porphyria), allergies, pregnancy, or breast-feeding. USE OF ESTRADERM (ESTRADIOL)IS NOT RECOMMENDED if you have certain medical conditions including undiagnosed abnormal vaginal bleeding, certain cancers (e.g., breast cancer, especially non-metastatic type), blood clots, liver disease, or active/recent stroke or heart attack. Contact your doctor or pharmacist if you have any questions or concerns about taking ESTRADERM (ESTRADIOL).

WARNING: Estrogens have been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause, especially in women with a uterus who receive estrogen-only hormone therapy. Estrogens may also increase the risk of cancer of the ovary/breast. Estrogen-containing medicines should not be used to prevent heart disease. Estrogen given in combination with another hormone (progestin) for replacement therapy can infrequently cause heart disease (e.g., heart attacks), stroke, serious blood clots, dementia, and cancer of the breast. These risks appear to depend on the length of time this medicine is used and the amount of estrogen per dose. Therefore, ESTRADERM (ESTRADIOL) should be used for the shortest possible length of time at the lowest effective dose, so you obtain the benefits and minimize the chance of serious side effects from long-term treatment. Consult your doctor or pharmacist for details. If you use this medicine for an extended period, you should be evaluated at least once yearly (see CAUTIONS section). ESTRADERM (ESTRADIOL) is not effective in preventing/treating a tendency toward miscarriages nor the threat of miscarriage. ESTRADERM (ESTRADIOL) must not be used during pregnancy because its use may result in birth defects or cancer later in the child's life (see CAUTIONS section). INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking corticosteroids (e.g., prednisone), hydantoins (e.g., phenytoin), or warfarin. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking any medicines which may affect certain liver enyzymes (CYP450-3A4 enzymes) including azole antifungals (e.g., ketoconazole, itraconazole), carbamazepine, cimetidine, macrolide antibiotics (e.g., clarithromycin, erythromycin), phenobarbital, rifamycins (e.g., rifampin), ritonavir, or St. John's wort. DO NOT START OR STOP ANY MEDICINE without doctor or pharmacist approval. Inform your doctor of any other medical conditions including a family medical history (e.g., especially breast lumps/cancer), asthma, diabetes, seizures, migraine headaches, kidney disease, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy, yellowing of eyes/skin during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids/endometriosis), cholesterol/lipid problems, gallbladder disease, excessive weight gain, certain blood disorder (porphyria), allergies, pregnancy, or breast-feeding. USE OF ESTRADERM (ESTRADIOL)IS NOT RECOMMENDED if you have certain medical conditions including undiagnosed abnormal vaginal bleeding, certain cancers (e.g., breast cancer, especially non-metastatic type), blood clots, liver disease, or active/recent stroke or heart attack. Contact your doctor or pharmacist if you have any questions or concerns about taking ESTRADERM (ESTRADIOL).